Abstract ♦ This paper primarily serves as a thought-provoking overview of the complex interconnections between companion animal loss, euthanasia, and veterinary burnout, integrating practical veterinary experiences with domestic research findings. To understand this phenomenon, I apply Paul Gilbert’s Compassion Focused Therapy (CFT) model, which divides emotion regulation into three pillars: the threat (red), the drive (blue), and the soothing (green) systems. The chronic stress of the veterinary profession causes abnormal overactivation of the red and blue systems, leading to the depletion of the green (soothing) system and resulting in burnout. From the owner's perspective, the loss of their companion animal can trigger an emotional regulation collapse, which may be further exacerbated by social rejection (disenfranchised grief). During the critical process of euthanasia, the nervous systems of both the veterinarian and the owner interact continuously through mirror neurons. The presence of a veterinarian who is able to connect with their own inner resources provides emotional security for the owner, which can have a positive impact on the grief process following companion animal loss.